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March 28th, 2012
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Kigtropin is taken once daily by injection under the skin (subcutaneously) . You, or your caregiver, should be taught how to give the injections. Your doctor will tell you how much Kigtropin to take and may change the dose depending on how you respond.
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The results of Kigtropin treatment may depend on your overall health condition, and:
the nature and location of your intestinal surgery or damage
the underlying cause of your surgery (e.g., Crohn’s disease, injury)
closely following all the treatment instructions given byyour doctor or dietitian
Following your diet is especially important to get the most benefit from treatment.
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March 28th, 2012
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Kigtropin 10iu
Recombinant Human Growth Hormone for Injection
[NAME OF THE MEDICINAL PRODUCT]
Generic Name: Recombinant Human Growth Hormone
Trade Name: KIGTROPIN
[INGREDIENTS]
Recombinant Human Growth Hormone and excipients.
Molecular Formula: C990H1528N262O300S7 with 191 amino acids residues.
Molecular Weight: 22125D
Origin of the Active Ingredient: KIGTROPIN is a Recombinants
Human Growth Hormone. KIGTROPIN is produced by recombinant DNA
technology in E.coli secretion expression system. KIGTROPIN has the
same amino acid sequence with 191 residues as the native human growth
hormone produced in the human body..
[CHARACTERS]
White Lyophilized powder.
[INDICATION]
Growth failure of children due to endogenous growth hormone
deficiency (GHD).
In adults with growth hormone deficiency, KIGTROPIN reduces
fat mass, increases muscle mass and improves energy, vitality and
subjective well-being. In patients suffering from severe burns, AIDS
associated muscle wasting, or undergoing major operations, KIGTROPIN
promotes wound healing, attenuates the protein-catabolic response and
improves whole-body nitrogen condition after operation.
[SPECIFICATIONS]
10IU/3.7mg/1.0ml/vial
[DOSAGE AND ADMINISTRATION]
Before administration, add 1ml of sterile water for injection
to the rhGH vial of Lyophilized powder along the wall slowly. Shake it
gently to fully dissolve the powder to get clarified solution. DO NOT
shake violently.
For anti-aging, general health & healing, fat mobilization, a
dose of 2-3 IU’s per day will be sufficient for the majority. A dose
of 1.5 to 2.0 IU’s is considered to be a full replacement dose for
those in their middle-age and beyond.
For gaining lean muscle and substantially improving body
composition, a dose of 4-8 IUs per day will be necessary. Most people
will respond very well at a dose of 4-5 IU’s per day. For maximum
benefit in this regard, the addition of Testosterone, Insulin, and
low-dose t3 would be something to seriously consider. More on this in
our comparative cycle guide of HGH/Insulin/IGF.
The recommended dosage for injection is 0.1-0.15IU/kg/day,
inject before sleeping daily at the same time and the injection site
should be changes frequently to prevent lipoatrophy at the site, or
follow the physician’s advice.
[ADVERSE REACTIONS]
Growth hormone may induce transient hyperglycosemia, which
usually recover to normal level over time or after drug
discontinuation.
About 1% children with microsomia in the clinical trial
presented side effects, which usually presented transient reactions at
the injection site (pain, tingling numbness, red swelling, etc) and
the symptoms of fluid retention (peripheral edema, arthralgia or
myalgia).These side effects usually appear at early stage and the
incidence rate decreases over time which rarely affects daily
activities.
Long-term injection of recombinant human growth hormone
results in antibody production in minority people, however, the
affinity of the antibody is low without exact clinical significance,
The antibody may be induced if the anticipant effect of growth is not
achieved, which may affect the efficacy if the affinity is over 2
mg/L.
[CONTRAINDICATIONS]
Children with closure of epiphysis are forbidden.
Patients with the progressive symptoms of tumor are forbidden.
Critical ill patients in acute shock stage of serious
systematic infection are forbidden.
[STORAGE]
Keep at 2-8 Degrees Celsius in the refrigerator, away from light.
Before reconstitution:
–If refrigerated between 2-8 Degrees Celsius, it’s good until expiration date.
–At room temperature (under 37oC) it’s good for over 30 days.
After reconstitution:
–Use Bacteriostatic Water to reconstitute and keep in 2-8oC, it will
be good for 20 days.
–Use Sterile Water to reconstitute and keep in 2-8oC. it will be good
for 72 hours.
[PACKAGE]
Tube-shaped antibiotics glass bottle, 10 bottles/inner box.
[SHELF LIFE]
Two years.
[EXECUTIVE STANDARD]
Pharmacopoeia of People’s Republic of China 2005 Edition 2
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March 21st, 2012
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